Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

by Tsuji, Akihito , Yamashita, Riu , Nakamura, Yoshiaki , Oki, Eiji , Morizane, Chigusa , Yamanaka, Takeharu , Esaki, Taito , Kato, Takeshi , Furuse, Junji , Yamaguchi, Kensei , Yasui, Hisateru , Goto, Masahiro , Sakamoto, Yasutoshi , Miki, Izumi , Kawamoto, Yasuyuki , Tsuchihara, Katsuya , Okamoto, Wataru , Ohtsu, Atsushi , Taniguchi, Hiroya , Nakajima, Takako , Kawakami, Hisato , Odegaard, Justin I. , Ueno, Makoto , Denda, Tadamichi , Nishida, Naohiro , Komatsu, Yoshito , Hata, Masayuki , Ikeda, Masafumi , Yamamoto, Yoshiyuki , Nishina, Tomohiro , Yamazaki, Kentaro , Bando, Hideaki , Kagawa, Yoshinori , Ohtsubo, Koushiro , Ichiki, Hiroko , Takahashi, Naoki , Yoshino, Takayuki , Kato, Ken , Matsuhashi, Nobuhisa

in 631/67/69 / 692/308/153 / 692/53/2423 / Adult / Biomarkers / Biomarkers, Tumor - blood / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer Research / Care and treatment / Circulating Tumor DNA - blood / Circulating Tumor DNA - genetics / Clinical trials / Deoxyribonucleic acid / Diagnosis / DNA / DNA sequencing / DNA, Neoplasm - blood / Gastrointestinal cancer / Gastrointestinal Neoplasms - blood / Gastrointestinal Neoplasms - genetics / Gastrointestinal Neoplasms - pathology / Genetic aspects / Genotype / Genotyping / Health aspects / High-Throughput Nucleotide Sequencing / Humans / Infectious Diseases / Japan - epidemiology / Letter / Male / Metabolic Diseases / Middle Aged / Molecular Medicine / Mutation - genetics / Neurosciences / Nucleotide sequence / Nucleotide sequencing / Observational studies / Oncology, Experimental / Patients / Precision Medicine / Solid tumors / Tumors

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

2020

Confirm

Do you wish to request the book?

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

Tsuji, Akihito,

Yamashita, Riu,

Nakamura, Yoshiaki,

Oki, Eiji,

Morizane, Chigusa,

Yamanaka, Takeharu,

Esaki, Taito,

Kato, Takeshi,

Furuse, Junji,

Yamaguchi, Kensei,

Yasui, Hisateru,

Goto, Masahiro,

Sakamoto, Yasutoshi,

Miki, Izumi,

Kawamoto, Yasuyuki,

Tsuchihara, Katsuya,

Okamoto, Wataru,

Ohtsu, Atsushi,

Taniguchi, Hiroya,

Nakajima, Takako,

Kawakami, Hisato,

Odegaard, Justin I.,

Ueno, Makoto,

Denda, Tadamichi,

Nishida, Naohiro,

Komatsu, Yoshito,

Hata, Masayuki,

Ikeda, Masafumi,

Yamamoto, Yoshiyuki,

Nishina, Tomohiro,

Yamazaki, Kentaro,

Bando, Hideaki,

Kagawa, Yoshinori,

Ohtsubo, Koushiro,

Ichiki, Hiroko,

Takahashi, Naoki,

Yoshino, Takayuki,

Kato, Ken,

Matsuhashi, Nobuhisa

2020

Overview

Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P < 0.0001) and improved the trial enrollment rate (9.5 versus 4.1%, P < 0.0001) without compromising treatment efficacy compared to tissue genotyping. We also describe the clonal architecture of ctDNA profiles in ~2,000 patients with advanced GI cancer, which reinforces the relevance of many targetable oncogenic drivers and highlights multiple new drivers as candidates for clinical development. ctDNA genotyping has the potential to accelerate innovation in precision medicine and its delivery to individual patients. An observational study on a large cohort of patients with gastrointestinal cancer demonstrates the utility of ctDNA analysis for accelerating the enrollment of patients in clinical trials with no accompanying deterioration in treatment efficacy.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Adult

/ Biomarkers, Tumor - blood

/ Biomedical and Life Sciences