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TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2

by Macintyre, Elizabeth , Nadel, Bertrand , Touzart, Aurore , Kaltenbach, Sophie , Cieslak, Agata , Balducci, Estelle , Steimlé, Thomas , Dombret, Hervé , Villarese, Patrick , Couronné, Lucile , Smith, Charlotte , Baruchel, André , Feroul, Mélanie , Boissel, Nicolas , Simonin, Mathieu , Payet-Bornet, Dominique , Asnafi, Vahid , Lhermitte, Ludovic , Dourthe, Marie-Emilie , Ifrah, Norbert

in Acute lymphoblastic leukemia / Antigens / B cells / Biochemistry, Molecular Biology / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer Research / Carcinogenesis / Carcinogenesis - genetics / Cell Transformation, Neoplastic - genetics / Correspondence / Genes / Genomes / Genomic Instability / Genomics / Hematology / Hematopoietic Stem Cells / Human health and pathology / Humans / Leukemia / Life Sciences / Lymphocytes T / Lymphoma / Malignancy / Mitochondrial DNA / Non-Hodgkin's lymphomas / Oncogenesis / Oncology / Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics / Proteins / T cell receptors / T cells / T-cell receptor excision circles (TREC) / Transcription Factors / Tumor suppressor genes / Tumorigenesis / Tumors / V(D)J recombination

2023

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TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2

2023

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TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2

2023

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Journal Article

TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2

Macintyre, Elizabeth,

Nadel, Bertrand,

Touzart, Aurore,

Kaltenbach, Sophie,

Cieslak, Agata,

Balducci, Estelle,

Steimlé, Thomas,

Dombret, Hervé,

Villarese, Patrick,

Couronné, Lucile,

Smith, Charlotte,

Baruchel, André,

Feroul, Mélanie,

Boissel, Nicolas,

Simonin, Mathieu,

Payet-Bornet, Dominique,

Asnafi, Vahid,

Lhermitte, Ludovic,

Dourthe, Marie-Emilie,

Ifrah, Norbert

2023

Overview

The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human lymphoid cancers. However, such molecular events have not been recurrently reported in clinical patient lymphoma/leukemia samples. Using a specifically designed NGS-capture pipeline, we here demonstrated the reintegration of T-cell receptor excision circles (TRECs) in 20/1533 (1.3%) patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Remarkably, the reintegration of TREC recurrently targeted the tumor suppressor gene, ZFP36L2, in 17/20 samples. Thus, our data identified a new and hardly detectable mechanism of gene deregulation in lymphoid cancers providing new insights in human oncogenesis.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

Acute lymphoblastic leukemia

/ Antigens

/ B cells

/ Biochemistry, Molecular Biology

/ Biomedical and Life Sciences

/ Biomedicine

/ Cancer