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Use of a new global indicator for vaccine safety surveillance and trends in adverse events following immunization reporting 2000–2015
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Use of a new global indicator for vaccine safety surveillance and trends in adverse events following immunization reporting 2000–2015
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Use of a new global indicator for vaccine safety surveillance and trends in adverse events following immunization reporting 2000–2015
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Journal Article
Use of a new global indicator for vaccine safety surveillance and trends in adverse events following immunization reporting 2000–2015
2018
Overview
Reporting of adverse events following immunization (AEFI) is a key component for functional vaccine safety monitoring system. The aim of our study is to document trends in the AEFI reporting ratio globally and across the six World Health Organization (WHO) regions. We describe the number of AEFI reports communicated each year through the World Health Organization/United Nations Children's Fund Joint Reporting Form on Immunization from 2000 to 2015. The AEFI reporting ratios (annual AEFI reports per 100,000 surviving infants) were calculated to identify WHO countries (n = 191 in 2000 and n = 194 by 2015) that met a minimal reporting ratio of 10, a target set by the Global Vaccine Action Plan for vaccine safety monitoring as a proxy measure for a functional AEFI reporting system. The number of countries reporting any AEFI fluctuated over time but with progress from 32 (17%) in 2000 to 124 (64%) in 2015. In 2015, the global average AEFI reporting ratio was 549 AEFI reports per 100,000 surviving infants. The number of countries with AEFI reporting ratios greater than 10 increased from 8 (4%) in 2000 to 81 (42%) in 2015. In 2015, 60% of countries in the WHO Region of the Americas reported at least 10 AEFI per 100,000 surviving infants, followed by 55% in European Region, 43% in Eastern Mediterranean Region, 33% in Western Pacific Region, 27% in South-East Asia Region and 21% in African Region. Overall, AEFI reporting has increased over the past sixteen years worldwide, but requires strengthening in a majority of low- and middle- income countries. The AEFI reporting ratio is useful for benchmarking and following trends over time; but does not provide information on the quality of the reporting system and does not guarantee capacity to detect and manage a vaccine safety problem at a national level. Additional efforts are required to ensure and improve data quality, AEFI reporting and surveillance of immunization safety in every country.
Publisher
Elsevier Ltd,Elsevier Limited,Elsevier Science
Subject
Adverse Drug Reaction Reporting Systems
/ Adverse events following immunization
/ Children
/ Europe
/ Global vaccine safety blueprint
/ Humans
/ income
/ Infants
/ Ratios
/ Safety
/ Trends
/ Vaccination - adverse effects
/ Vaccination - statistics & numerical data
/ Vaccines
/ Vaccines - administration & dosage
/ Viruses
