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Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery
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Journal Article
Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery
2013
Overview
Transcutaneous immunization (TCI) systems that use the skin's immune function are promising needle-free, easy-to-use, and low-invasive vaccination alternative to conventional, injectable vaccination methods. To develop effective TCI systems, it is essential to establish fundamental techniques and technologies that deliver antigenic proteins to antigen-presenting cells in the epidermis and dermis while overcoming the barrier function of the stratum corneum. In this review, we provide an outline of recent trends in the development of techniques for the delivery of antigenic proteins and of the technologies used to enhance TCI systems. We also introduce basic and clinical research involving our TCI systems that incorporate several original devices.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Antigens - administration & dosage
/ Biological and medical sciences
/ dermis
/ Drug Delivery Systems - instrumentation
/ Drug Delivery Systems - methods
/ E coli
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Lipids
/ proteins
/ Review
/ Severe acute respiratory syndrome
/ Skin
/ Studies
/ Vaccination - instrumentation
/ Vaccines
/ Vaccines - administration & dosage
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
