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Photodynamic antimicrobial chemotherapy in mice with Pseudomonas aeruginosa-infected wounds
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Photodynamic antimicrobial chemotherapy in mice with Pseudomonas aeruginosa-infected wounds
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Photodynamic antimicrobial chemotherapy in mice with Pseudomonas aeruginosa-infected wounds
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Journal Article
Photodynamic antimicrobial chemotherapy in mice with Pseudomonas aeruginosa-infected wounds
2020
Overview
This study examined the antibacterial effect of protoporphyrin IX-ethylenediamine derivative (PPIX-ED)-mediated photodynamic antimicrobial chemotherapy (PPIX-ED-PACT) against Pseudomonas aeruginosa in vitro and in vivo. PPIX-ED potently inhibited the growth of Pseudomonas aeruginosa by inducing reactive oxygen species production via photoactivation. Atomic force microscopy revealed that PPIX-ED-PACT induced the leakage of bacterial content by degrading the bacterial membrane and wall. As revealed using acridine orange/ethidium bromide staining, PPIX-ED-PACT altered the permeability of the bacterial membrane. In addition, the antibacterial effect of PPIX-ED-PACT was demonstrated in an in vivo model of P. aeruginosa-infected wounds. PPIX-ED (100 [mu]M) decreased the number of P. aeruginosa colony-forming units by 4.2 log.sub.10 . Moreover, histological analysis illustrated that the wound healing rate was 98% on day 14 after treatment, which was 10% higher than that in the control group. According to the present findings, PPIX-ED-PACT can effectively inhibit the growth of P. aeruginosa in vitro and in vivo.
Publisher
Public Library of Science,Public Library of Science (PLoS)
