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Genomic characterization of Streptococcus parasuis, a close relative of Streptococcus suis and also a potential opportunistic zoonotic pathogen
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Genomic characterization of Streptococcus parasuis, a close relative of Streptococcus suis and also a potential opportunistic zoonotic pathogen
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Journal Article
Genomic characterization of Streptococcus parasuis, a close relative of Streptococcus suis and also a potential opportunistic zoonotic pathogen
2022
Overview
Streptococcus parasuis
(
S. parasuis
) is a close relative of
Streptococcus suis
(
S. suis
), composed of former members of
S. suis
serotypes 20, 22 and 26.
S. parasuis
could infect pigs and cows, and recently, human infection cases have been reported, making
S. parasuis
a potential opportunistic zoonotic pathogen. In this study, we analysed the genomic characteristics of
S. parasuis
, using pan-genome analysis, and compare some phenotypic determinants such as capsular polysaccharide, integrative conjugative elements, CRISPR-Cas system and pili, and predicted the potential virulence genes by associated analysis of the clinical condition of isolated source animals and genotypes. Furthermore, to discuss the relationship with
S. suis
, we compared these characteristics of
S. parasuis
with those of
S. suis
. We found that the characteristics of
S. parasuis
are similar to those of
S. suis
, both of them have “open” pan-genome, their antimicrobial resistance gene profiles are similar and a
srtF
pilus cluster of
S. suis
was identified in
S. parasuis
genome. But
S. parasuis
still have its unique characteristics, two novel pilus clusters are and three different type CRISPR-Cas system were found. Therefore, this study provides novel insights into the interspecific and intraspecific genetic characteristics of
S. parasuis
, which can be useful for further study of this opportunistic pathogen, such as serotyping, diagnostics, vaccine development, and study of the pathogenesis mechanism.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
