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Evolution of MRSA During Hospital Transmission and Intercontinental Spread
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Evolution of MRSA During Hospital Transmission and Intercontinental Spread
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Journal Article
Evolution of MRSA During Hospital Transmission and Intercontinental Spread
2010
Overview
Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ bacteria
/ Biological and medical sciences
/ Cross Infection - epidemiology
/ Cross Infection - microbiology
/ Cross Infection - transmission
/ Fundamental and applied biological sciences. Psychology
/ Genomes
/ Genomics
/ Humans
/ methicillin-resistant Staphylococcus aureus
/ Methicillin-Resistant Staphylococcus aureus - classification
/ Methicillin-Resistant Staphylococcus aureus - genetics
/ Methicillin-Resistant Staphylococcus aureus - isolation & purification
/ Polymorphism, Single Nucleotide
/ South America - epidemiology
/ Staphylococcal Infections - epidemiology
/ Staphylococcal Infections - microbiology
