Asset Details
Do you wish to reserve the book?
Antigen Recognition by Variable Lymphocyte Receptors
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Antigen Recognition by Variable Lymphocyte Receptors
Do you wish to request the book?
Antigen Recognition by Variable Lymphocyte Receptors
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Antigen Recognition by Variable Lymphocyte Receptors
2008
Overview
Variable lymphocyte receptors (VLRs) rather than antibodies play the primary role in recognition of antigens in the adaptive immune system of jawless vertebrates. Combinatorial assembly of leucine-rich repeat (LRR) gene segments achieves the required repertoire for antigen recognition. We have determined a crystal structure for a VLR-antigen complex, VLR RBC36 in complex with the H-antigen trisaccharide from human blood type O erythrocytes, at 1.67 angstrom resolution. RBC36 binds the H-trisaccharide on the concave surface of the LRR modules of the solenoid structure where three key hydrophilic residues, multiple van der Waals interactions, and the highly variable insert of the carboxyl-terminal LRR module determine antigen recognition and specificity. The concave surface assembled from the most highly variable regions of the LRRs, along with diversity in the sequence and length of the highly variable insert, can account for the recognition of diverse antigens by VLRs.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
ABO Blood-Group System - chemistry
/ ABO Blood-Group System - immunology
/ ABO Blood-Group System - metabolism
/ Animals
/ Antigens
/ Biological and medical sciences
/ Cell structures and functions
/ Fish
/ Fundamental and applied biological sciences. Psychology
/ genes
/ Humans
/ Hydrophobic and Hydrophilic Interactions
/ leucine
/ Molecular and cellular biology
/ Protein Structure, Secondary
/ Receptors, Antigen - chemistry
/ Receptors, Antigen - immunology
/ Receptors, Antigen - metabolism
/ Structure in molecular biology
/ Zoology
