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The nature and identification of quantitative trait loci: a community's view

by Farber, Charles R , Blankenhorn, Elizabeth P , Cook, Melloni , Williams, Robert W , Angel, Joe M , Flaherty, Lorraine , Doerge, R W , Darvasi, Ariel , Mock, Beverly A , Vadasz, Csaba , Mittlemann, Guy , Iraqi, Fuad F , Hitzemann, Robert , Zou, Fei , O'Hara, Bruce F , Palmer, Abraham A , Cheverud, James M , Blizard, David A , Settle, Stephen , Morahan, Grant , Montagutelli, Xavier , Van Zant, Gary , Johnson, Thomas E , Teuscher, Cory , Siracusa, Linda D , Bureau, Jean-Francoise , Mehrabian, Margarete , Seltzer, Ze'ev , Wakeland, Edward , Rosemann, Michael , Osadchuk, Alexander V , Hunter, Kent , Peirce, Jeremy L , Rosen, Glenn D , Toye, Ayo A , Chesler, Elissa J , Elliot, Rosemary W , Jansen, Ritsert C , Abiola, Oduola , Crusio, Wim E , Manly, Kenneth F , Spearow, Jimmy L , Jones, Byron C , Medrano, Juan F , Nagase, Hiroki , Shimomura, Kazuhiro , Zhang, Huang-Ge , de Haan, Gerald , Paigen, Beverly , Pomp, Daniel , Mountz, John D , Bolivar, Valerie , Toth, Linda A , Gibson, John P , Gershenfeld, Howard , Dermant, Peter , Brockmann, Gundrun A , Lammert, Frank , Sikela, James M , Crabbe, John C , Kempermann, Gerd , Matthews, Douglas B , Himmelbauer, Heinz , Shou, Siming , Churc

in Agriculture / Animal genetics / Animal Genetics and Genomics / Animals / Animals, Genetically Modified / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Cancer Research / Chromosome Mapping - standards / Diverse techniques / Fundamental and applied biological sciences. Psychology / Gene Function / Genetics / guidelines-2 / Human Genetics / Humans / Life Sciences / Molecular and cellular biology / Quantitative Trait Loci

2003

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2003

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2003

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Journal Article

The nature and identification of quantitative trait loci: a community's view

Farber, Charles R,

Blankenhorn, Elizabeth P,

Cook, Melloni,

Williams, Robert W,

Angel, Joe M,

Flaherty, Lorraine,

Doerge, R W,

Darvasi, Ariel,

Mock, Beverly A,

Vadasz, Csaba,

Mittlemann, Guy,

Iraqi, Fuad F,

Hitzemann, Robert,

Zou, Fei,

O'Hara, Bruce F,

Palmer, Abraham A,

Cheverud, James M,

Blizard, David A,

Settle, Stephen,

Morahan, Grant,

Montagutelli, Xavier,

Van Zant, Gary,

Johnson, Thomas E,

Teuscher, Cory,

Siracusa, Linda D,

Bureau, Jean-Francoise,

Mehrabian, Margarete,

Seltzer, Ze'ev,

Wakeland, Edward,

Rosemann, Michael,

Osadchuk, Alexander V,

Hunter, Kent,

Peirce, Jeremy L,

Rosen, Glenn D,

Toye, Ayo A,

Chesler, Elissa J,

Elliot, Rosemary W,

Jansen, Ritsert C,

Abiola, Oduola,

Crusio, Wim E,

Manly, Kenneth F,

Spearow, Jimmy L,

Jones, Byron C,

Medrano, Juan F,

Nagase, Hiroki,

Shimomura, Kazuhiro,

Zhang, Huang-Ge,

de Haan, Gerald,

Paigen, Beverly,

Pomp, Daniel,

Mountz, John D,

Bolivar, Valerie,

Toth, Linda A,

Gibson, John P,

Gershenfeld, Howard,

Dermant, Peter,

Brockmann, Gundrun A,

Lammert, Frank,

Sikela, James M,

Crabbe, John C,

Kempermann, Gerd,

Matthews, Douglas B,

Himmelbauer, Heinz,

Shou, Siming,

Churc

2003

Overview

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

Agriculture

/ Animal genetics

/ Animal Genetics and Genomics

/ Animals

/ Animals, Genetically Modified

/ Biological and medical sciences

/ Biomedical and Life Sciences