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Journal Article
Cushing’s disease
2012
Overview
Cushing’s disease, or pituitary ACTH dependent Cushing’s syndrome, is a rare disease responsible for increased morbidity and mortality. Signs and symptoms of hypercortisolism are usually non specific: obesity, signs of protein wasting, increased blood pressure, variable levels of hirsutism. Diagnosis is frequently difficult, and requires a strict algorithm. First-line treatment is based on transsphenoidal surgery, which cures 80% of ACTH-secreting microadenomas. The rate of remission is lower in macroadenomas. Other therapeutic modalities including anticortisolic drugs, radiation techniques or bilateral adrenalectomy will thus be necessary to avoid long-term risks (metabolic syndrome, osteoporosis, cardiovascular disease) of hypercortisolism. This review summarizes potential pathophysiological mechanisms, diagnostic approaches, and therapies.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ ACTH-Secreting Pituitary Adenoma - diagnosis
/ ACTH-Secreting Pituitary Adenoma - pathology
/ ACTH-Secreting Pituitary Adenoma - surgery
/ Disease
/ France
/ Humans
/ Medicine
/ Obesity
/ Pituitary ACTH Hypersecretion - diagnosis
/ Pituitary ACTH Hypersecretion - pathology
/ Pituitary ACTH Hypersecretion - surgery
/ Pituitary ACTH Hypersecretion - therapy
/ Pituitary Neoplasms - diagnosis
/ Pituitary Neoplasms - pathology
/ Pituitary Neoplasms - surgery
/ Review
/ Tumors
