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Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum
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Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum
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Journal Article
Catestatin, an endogenous Chromogranin A-derived peptide, inhibits in vitro growth of Plasmodium falciparum
2010
Overview
Catestatin, an endogenous peptide derived from bovine chromogranin A, and its active domain cateslytin display powerful antimicrobial activities. We have tested the activities of catestatin and other related peptides on the growth of Plasmodium falciparum in vitro. Catestatin inhibits growth of the chloroquine-sensitive strain of P. falciparum 3D7, exhibiting 88% inhibition at 20 μM. A similar partial inhibition of parasite growth was observed for the chloroquine-resistant strain, 7G8 (64%,) and the multidrug-resistant strain, W2 (62%). In the presence of parasite-specific lactate dehydrogenase, a specific protein-protein interaction between catestatin and plasmepsin II precursor was demonstrated. In addition, catestatin partially inhibited the parasite-specific proteases plasmepsin in vitro. A specific interaction between catestatin and plasmepsins II and IV from P. falciparum and plasmepsin IV from the three remaining species of Plasmodium known to infect man was observed, suggesting a catestatin-induced reduction in availability of nutrients for protein synthesis in the parasite.
Publisher
Basel : SP Birkhäuser Verlag Basel,SP Birkhäuser Verlag Basel,Springer Nature B.V,Springer Verlag
Subject
/ Aspartic Acid Endopeptidases - antagonists & inhibitors
/ Biochemistry, Molecular Biology
/ Biomedical and Life Sciences
/ Cattle
/ Chromogranin A - chemical synthesis
/ Chromogranin A - pharmacology
/ Dose-Response Relationship, Drug
/ L-Lactate Dehydrogenase - antagonists & inhibitors
/ Malaria
/ Peptide Fragments - chemical synthesis
/ Peptide Fragments - chemistry
/ Peptide Fragments - pharmacology
/ Peptides
/ Plasmodium falciparum - drug effects
/ Plasmodium falciparum - growth & development
/ protein-protein interactions
/ Proteins
