Journal Article

Gut mycobiome alterations and implications for liver diseases

Schnabl, Bernd, Zeng, Suling

2024

Overview

Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfunction and allow fungal products to translocate to the liver causing progression of disease. This review explores recent progress in understanding the compositional and functional diversity of gut mycobiome signatures across different liver diseases. It delves into causative connections between gut fungi and liver diseases. We emphasize the significance of fungal translocation, with a particular focus on fungal-derived metabolites and immune cells induced by fungi, as key contributors to liver disease. Furthermore, we review the potential impact of the intrahepatic mycobiome on the progression of liver diseases.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Analysis / Animals / Antifungal agents / Biology and Life Sciences / Care and treatment / Composition / Diagnosis / Digestive system / Dosage and administration / Dysbacteriosis / Dysbiosis - microbiology / Feces / Fungi / Fungi - pathogenicity / Gastrointestinal Microbiome - physiology / Gastrointestinal tract / Geography / Global health / Humans / Immune system / Intestinal microflora / Liver / Liver cirrhosis / Liver diseases / Liver Diseases - microbiology / Medicine and Health Sciences / Metabolism / Metabolites / Microbiomes / Microbiota (Symbiotic organisms) / Mycobiome / Pathophysiology / Pharmaceuticals / Physiology / Public health / R&D / Research & development / Review / Risk factors / RNA sequencing / Translocation