Journal Article

Association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein and neutrophil-to-lymphocyte ratio in middle-aged and older adults with metabolic syndrome in Taiwan: a cross-sectional study

Syauqy, Ahmad, Chao, Jane C.-J., Rau, Hsiao-Hsien, Hsu, Chien-Yeh

2018

Overview

Background Metabolic syndrome is commonly associated with inflammation. The underlying factors of inflammation in metabolic syndrome are not fully understood. The objective of the study was to determine the association of dietary patterns, anthropometric measurements, and metabolic parameters with inflammatory markers in middle-aged and older adults with metabolic syndrome in Taiwan. Methods A total of 26,016 subjects aged ≥35 y with metabolic syndrome were recruited from Mei Jau institution between 2004 and 2013 for a cross sectional study. Metabolic syndrome was defined by the International Diabetes Federation. Multivariate logistic regression was performed to evaluate the association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) in men and women with metabolic syndrome. Crude and adjusted models were analyzed by gender. Results The western dietary pattern, obesity, high body fat, high waist or hip circumference, and high waist-to-hip ratio were significantly associated with increased odds ratios of high CRP and NLR in both genders. High systolic or diastolic blood pressure (BP), low high-density lipoprotein-cholesterol (HDL-C), high low-density lipoprotein-cholesterol (LDL-C), high total cholesterol (TC), high serum triglycerides (TG), and high fasting blood glucose (FBG) were significantly correlated with increased odds ratios of high CRP in both genders. Low HDL-C, high LDL-C, high serum TG, and high FBG were significantly associated with increased odds ratios of high NLR in both genders. However, high systolic (OR = 1.124, 95% CI 1.047–1.206, P  < 0.01) or diastolic BP (OR = 1.176, 95% CI 1.087–1.273, P  < 0.001) and high TC (OR = 1.138, 95% CI 1.062–1.220, P  < 0.001) were significantly correlated with increased odds ratios of high NLR only in men. Conclusions The western dietary pattern, obese-related anthropometric parameters, and most components of metabolic syndrome are positively associated with CRP levels and NLR in men and women with metabolic syndrome.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Aged / Anthropometric measurements / Anthropometry / Atherosclerosis / Blood cell count / blood glucose / Blood pressure / blood serum / Body fat / Body mass index / Body measurements / Body size / C-reactive protein / Cholesterol / Clinical Nutrition / Cross-sectional studies / Development and progression / Diabetes / Diabetes mellitus / diastolic blood pressure / Dietary patterns / eating habits / elderly / Fasting / Food habits / gender / Health aspects / Health Promotion and Disease Prevention / Heart failure / High density lipoprotein / Hip / hip circumference / Inflammation / Lipoproteins / Low density lipoprotein / Lymphocytes / Medical screening / Medicine / Medicine & Public Health / men / Metabolic disorders / Metabolic parameters / Metabolic syndrome / Metabolic syndrome X / Middle age / Middle aged persons / Neutrophil-to-lymphocyte ratio / Neutrophils / Nutrition research / Obesity / odds ratio / Older people / Proteins / Public health / Ratios / regression analysis / Risk factors / Taiwan / triacylglycerols / Triglycerides / waist / waist-to-hip ratio / women