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The gastrointestinal mucus system in health and disease
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Journal Article
The gastrointestinal mucus system in health and disease
2013
Overview
Gastrointestinal mucus is the first line of defence against bac-teria; the organization of this protective system varies markedly along the digestive tract. In this Review, the authors provide an overview of the mucus system and discuss the role of mucus in health and disease.
Mucins—large, highly glycosylated proteins—are important for the luminal protection of the gastrointestinal tract. Enterocytes have their apical surface covered by transmembrane mucins and goblet cells produce the secreted gel-forming mucins that form mucus. The small intestine has a single unattached mucus layer, which in cystic fibrosis becomes attached, accounting for the intestinal manifestations of this disease. The stomach and colon have two layers of mucus; the inner layer is attached and the outer layer is less dense and unattached. In the colon, the outer mucus layer is the habitat for commensal bacteria. The inner mucus layer is impervious to bacteria and is renewed every hour by surface goblet cells. The crypt goblet cells have the ability to restitute the mucus layer by secretion, for example after an ischaemic challenge. Proteases of certain parasites and some bacteria can cleave mucins and dissolve the mucus as part of their pathogenicity. The inner mucus layer can, however, also become penetrable to bacteria by several other mechanisms, including aberrations in the immune system. When bacteria reach the epithelial surface, the immune system is activated and inflammation is triggered. This mechanism might occur in some types of ulcerative colitis.
Key Points
Gastrointestinal mucus is the first line of defence against bacteria
The mucus layer in the small intestine is freely movable and carries bacteria distally
In cystic fibrosis, the small intestinal mucus is not freely movable, which might explain the intestinal symptoms of this disease
The colon handles its large bacterial load with a two-layered mucus system, in which the inner layer normally remains impenetrable to bacteria.
Defective functioning of the inner mucus layer of the colon might be a pathophysiological mechanism for colitis and infectious diseases
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Gastrointestinal Diseases - microbiology
/ Gastrointestinal Diseases - physiopathology
/ Gastrointestinal Tract - microbiology
/ Gastrointestinal Tract - physiology
/ Humans
/ Intestine, Small - physiology
/ Intestine, Small - physiopathology
/ Medicine
/ Medicinska och farmaceutiska grundvetenskaper
/ Mucins
