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Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

by van der Harst, Pim , Großhennig, Anika , Perret, Claire , Ziegler, Andreas , Preuss, Michael , Wright, Ben J , Ouwehand, Willem , Munteanu, Alexandru , Meitinger, Thomas , Germain, Cécile , Thompson, John R , Arveiler, Dominique , Schreiber, Stefan , Ruidavets, Jean-Bernard , Erdmann, Jeanette , Evans, Alun , Hengstenberg, Christian , Schrezenmeir, Jürgen , Samani, Nilesh J , Schunkert, Heribert , El Mokhtari, Nour E , Hall, Alistair S , Cambien, Francois , Rubin, Diana , Linsel-Nitschke, Patrick , Luc, Gérald , Morrison, Caroline , Meisinger, Christa , Stark, Klaus , Braund, Peter S , Neureuther, Katharina , König, Inke R , Trégouët, David-Alexandre , Wichmann, H-Erich , DeSuremain, Maylis , Schäfer, Arne , Tiret, Laurence , Ball, Stephen G , Balmforth, Anthony J , Bugert, Peter

in Agriculture / Animal Genetics and Genomics / Apolipoprotein A-II - genetics / Bioinformatics / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / brief-communication / Cancer Research / Cardiology. Vascular system / Cardiovascular disease / Case-Control Studies / Computer Science / Coronary Artery Disease - genetics / Coronary heart disease / Distributed, Parallel, and Cluster Computing / Frequency distribution / Fundamental and applied biological sciences. Psychology / Gene Frequency / Gene Function / Genetic aspects / Genetic Predisposition to Disease / Genetic susceptibility / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Haplotypes / Health aspects / Heart / Human Genetics / Humans / Life Sciences / Lipoprotein(a) - genetics / Medical sciences / Multigene Family / Organic Cation Transport Proteins - genetics / Polymorphism, Single Nucleotide / Quantitative Methods / Quantitative Trait Loci / Risk Factors / Single nucleotide polymorphisms / Studies

2009

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Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

2009

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Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

2009

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Journal Article

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

van der Harst, Pim,

Großhennig, Anika,

Perret, Claire,

Ziegler, Andreas,

Preuss, Michael,

Wright, Ben J,

Ouwehand, Willem,

Munteanu, Alexandru,

Meitinger, Thomas,

Germain, Cécile,

Thompson, John R,

Arveiler, Dominique,

Schreiber, Stefan,

Ruidavets, Jean-Bernard,

Erdmann, Jeanette,

Evans, Alun,

Hengstenberg, Christian,

Schrezenmeir, Jürgen,

Samani, Nilesh J,

Schunkert, Heribert,

El Mokhtari, Nour E,

Hall, Alistair S,

Cambien, Francois,

Rubin, Diana,

Linsel-Nitschke, Patrick,

Luc, Gérald,

Morrison, Caroline,

Meisinger, Christa,

Stark, Klaus,

Braund, Peter S,

Neureuther, Katharina,

König, Inke R,

Trégouët, David-Alexandre,

Wichmann, H-Erich,

DeSuremain, Maylis,

Schäfer, Arne,

Tiret, Laurence,

Ball, Stephen G,

Balmforth, Anthony J,

Bugert, Peter

2009

Overview

Using a haplotype-based approach, David-Alexandre Trégouët and colleagues report that the SLC22A3-LPAL2-LPA gene cluster is associated with risk of coronary artery disease. We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

Agriculture

/ Animal Genetics and Genomics

/ Apolipoprotein A-II - genetics

/ Bioinformatics

/ Biological and medical sciences

/ Biomedical and Life Sciences

/ Biomedicine