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Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
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Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
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Journal Article
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
2020
Overview
T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses.Recent studies have shown T cell reactivity to SARS-CoV-2 in 20–50% of unexposed individuals; it is speculated that this is due to T cell memory to common cold coronaviruses. Here, Crotty and Sette discuss the potential implications of these findings for disease severity, herd immunity and vaccine development.
Publisher
Nature Publishing Group
