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Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain?
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Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain?
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Journal Article
Can the low and high b-value distribution influence the pseudodiffusion parameter derived from IVIM DWI in normal brain?
2020
Overview
Background
Our study aims to reveal whether the low b-values distribution, high b-values upper limit, and the number of excitation (NEX) influence the accuracy of the intravoxel incoherent motion (IVIM) parameter derived from multi-b-value diffusion-weighted imaging (DWI) in the brain.
Methods
This prospective study was approved by the local Ethics Committee and informed consent was obtained from each participant. The five consecutive multi-b DWI with different b-value protocols (0–3500 s/mm
2
) were performed in 22 male healthy volunteers on a 3.0-T MRI system. The IVIM parameters from normal white matter (WM) and gray matter (GM) including slow diffusion coefficient (D), fast perfusion coefficient (D*) and perfusion fraction (f) were compared for differences among defined groups with different IVIM protocols by one-way ANOVA.
Results
The D* and f value of WM or GM in groups with less low b-values distribution (less than or equal to 5 b-values) were significantly lower than ones in any other group with more low b-values distribution (all
P
< 0.05), but no significant differences among groups with more low b-values distribution (
P
> 0.05). In addition, no significant differences in the D, D* and f value of WM or GM were found between group with one and more NEX of low b-values distribution (all
P
> 0.05). IVIM parameters in normal WM and GM strongly depended on the choice of the high b-value upper limit.
Conclusions
Metrics of IVIM parameters can be affected by low and high b value distribution. Eight low b-values distribution with high b-value upper limit of 800–1000 s/mm
2
may be the relatively proper set when performing brain IVIM studies.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
