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Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese
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Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese
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Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese
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Journal Article
Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese
2019
Overview
Background
Evidence shows that low serum vitamin D concentrations account for an increased risk of obesity by inducing vitamin D receptor
(VDR)
hypofunction. Although the correlation between single nucleotide polymorphisms (SNPs) of
VDR
gene and obesity-related anthropometric measures (such as body mass index [BMI] and waist circumference[WC]) has already been tested, there are only few studies on the association between direct measures of body fat percentage (BFP) and triceps skinfold thickness and the SNPs of
VDR
. The aim of the present study was to evaluate the effect of
VDR
gene polymorphism on multiple obesity indexes in Han Chinese, including BMI, WC, BFP and triceps skinfold thickness.
Methods
In this cross-sectional study, five hundred and seventeen healthy Chinese adults were enrolled in the trial. Four loci in
VDR
gene (rs2228570 [FokI], rs2189480, rs2239179 and rs7975232[ApaI]) were genotyped by TaqMan probe assays. Obesity indexes including BMI, WC, BFP and triceps skinfold thickness were used to evaluate the relationship to the
VDR
SNPs. Multiple logistic regression, linear regression and general multifactor dimensionality reduction (GMDR) were performed to analyze the correlation of
VDR
gene and obesity indexes.
Results
None of the
VDR
SNPs were associated with BMI and WC, the C allele of FokI and the T allele of ApaI were associated with an increase in BFP (β = 0.069
,P
= 0.007; β = 0.087,
P
= 0.022 respectively); the G allele of rs2239179 and the T allele of ApaI were associated with an increase in triceps skin fold thickness (β = 0.074,
P
= 0.001; β = 0.122,
P
< 0.001 respectively). In regards to adiposity-related metabolic parameters, we found that the GT genotype of ApaI was associated with higher level of total cholesterol (TC) (
P
= 0.013) and Low-density lipoprotein cholesterol (LDL-C) (
P
= 0.001).
Conclusions
Though we failed to prove that
VDR
SNPs were in correlation with BMI and WC, we did establish the association between
VDR
variants and BFP, as well as triceps skinfold thickness. Data obtained suggested that the
VDR
variants play an important role in regulating adipose tissue activity and adiposity among Han Chinese.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
