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Untargeted high-resolution plasma metabolomic profiling predicts outcomes in patients with coronary artery disease

by Ko, Yi-An , Uppal, Karan , Mehta, Anurag , Kim, Jeong Hwan , Jones, Dean P. , Sperling, Laurence S. , Dhindsa, Devinder S. , Nayak, Aditi , Sun, Yan V. , Tahhan, Ayman S. , Hayek, Salim S. , Mehta, Puja K. , Quyyumi, Arshed A. , Liu, Chang

in Angiography / Asparagine / Bioinformatics / Biology and Life Sciences / Cardiac catheterization / Cardiology / Cardiovascular disease / Carnitine / Chromatography / Coronary artery / Coronary artery disease / Coronary heart disease / Coronary vessels / Critical care / Enrollments / Epidemiology / Health risks / Heart diseases / High resolution / Intubation / Laboratories / Liquid chromatography / Lysine / Mass spectrometry / Mass spectroscopy / Medical records / Medicine / Medicine and Health Sciences / Metabolic pathways / Metabolism / Metabolites / Metabolomics / Methods / Mortality / Mortality risk / Patient outcomes / Plasma / Public health / Reclassification / Risk / Risk assessment / Statistical analysis / Tryptophan / Tyrosine / Urea

2020

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Untargeted high-resolution plasma metabolomic profiling predicts outcomes in patients with coronary artery disease

2020

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Untargeted high-resolution plasma metabolomic profiling predicts outcomes in patients with coronary artery disease

2020

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Journal Article

Untargeted high-resolution plasma metabolomic profiling predicts outcomes in patients with coronary artery disease

Ko, Yi-An,

Uppal, Karan,

Mehta, Anurag,

Kim, Jeong Hwan,

Jones, Dean P.,

Sperling, Laurence S.,

Dhindsa, Devinder S.,

Nayak, Aditi,

Sun, Yan V.,

Tahhan, Ayman S.,

Hayek, Salim S.,

Mehta, Puja K.,

Quyyumi, Arshed A.,

Liu, Chang

2020

Overview

Approach and results Differential regulation of six metabolic pathways involved in myocardial energetics and systemic inflammation is independently associated with mortality in patients with CAD. A novel risk score consisting of representative metabolites is highly predictive of mortality.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Angiography

/ Asparagine

/ Bioinformatics

/ Biology and Life Sciences

/ Cardiac catheterization

/ Cardiology

/ Cardiovascular disease