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Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks
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Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks
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Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks
Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks
Journal Article

Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks

2010
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Overview
  In many experimental assays, such generic interactions are rightfully filtered out. [...]the definition of PPI has to consider (1st) the interaction interface should be intentional and not accidental, i.e., the result of specific selected biomolecular events/forces; and (2nd) the interaction interface should be non-generic, i.e., evolved for a specific purpose distinct from totally generic functions such as protein production, degradation, and others. [...]the use of PPI data combined with related pathways allows for a useful and detailed exploration of protein networks.