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A case report of disseminated histoplasmosis and concurrent cryptococcal meningitis in a patient treated with ruxolitinib
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A case report of disseminated histoplasmosis and concurrent cryptococcal meningitis in a patient treated with ruxolitinib
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A case report of disseminated histoplasmosis and concurrent cryptococcal meningitis in a patient treated with ruxolitinib
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Journal Article
A case report of disseminated histoplasmosis and concurrent cryptococcal meningitis in a patient treated with ruxolitinib
2019
Overview
Background
Ruxolitinib is a highly potent janus kinase inhibitor that places its users at risk for various bacterial infections and viral reactivation. However new reports are also emerging that suggest greater immunosuppression and risk for fungal disease.
Case presentation
We report the case of a 51 year-old veteran from Guam, treated with ruxolitinib for polycythemia vera, who developed disseminated histoplasmosis and concurrent cryptococcal meningitis.
Conclusion
This case draws attention to the degree of immunosuppression that may be seen with this drug and the need for heightened vigilance for opportunistic infections in those treated with inhibitors of janus kinase/signal transducers and activators of transcription (JAK/STAT) such as ruxolitinib.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Antigens
/ Bacterial and fungal diseases
/ Complications and side effects
/ Guam
/ Histoplasmosis - chemically induced
/ Histoplasmosis - complications
/ Humans
/ Immune Tolerance - drug effects
/ Invasive Fungal Infections - chemically induced
/ Invasive Fungal Infections - complications
/ Invasive Fungal Infections - pathology
/ Kinases
/ Male
/ Medicine
/ Meningitis, Cryptococcal - chemically induced
/ Meningitis, Cryptococcal - complications
/ Meningitis, Cryptococcal - pathology
/ Patients
/ Polycythemia Vera - drug therapy
/ Urine
/ Veterans
