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Hepatitis viruses in Ethiopia: a systematic review and meta-analysis
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Hepatitis viruses in Ethiopia: a systematic review and meta-analysis
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Journal Article
Hepatitis viruses in Ethiopia: a systematic review and meta-analysis
2016
Overview
Background
The existing seroepidemiological data on viral hepatitis in Ethiopia showed a wide variation in prevalence pattern and the clinical and public health burden have been underestimated. The aim of this systematic review and meta-analysis was to provide a clear and comprehensive estimation of viral hepatitis epidemiology and the potential clinical burdens in Ethiopia.
Methods
A comprehensive literature search was carried out from five decades (1968–2015) published studies from biomedical databases; PubMed, Google scholar, Medline and Web of Science.
Results
The overall pooled prevalence of hepatitis B virus (HBV) was 7.4% (95%CI: 6.5–8.4). The pooled prevalence among subgroups showed 5.2% (95%CI: 3.7–7.4) in human immunodeficiency virus (HIV) infected individuals, 8.0% (95%CI: 5.9–10.7) in community based studies, 8.4% (95%CI: 5.4–12.7) in blood donors, 11.0% (95%CI: 7.5–15.9) in immigrants and 6.9% (95%CI: 5.6–8.5) in other groups. Among study parameters considered during meta-regression analysis, only study years were associated with a decreasing HBV prevalence rate over time. The overall pooled prevalence of anti-hepatitis C virus antibody (anti-HCV) was 3.1% (95%CI: 2.2–4.4). Unlike HBV, the anti-HCV prevalence in HIV infected individuals was higher (5.5%, 95%CI: 3.8–7.8%,
p
= 0.01) than the prevalence observed in the other subgroup of study population. Although relatively few data were available, hepatitis virus A (HAV), D (HDV) and E (HEV) were also circulated in Ethiopia.
Conclusions
This review indicates that all types of viral hepatitis origins are endemic in Ethiopia. Adapting a recommended diagnostic and treatment algorithm of viral hepatitis in the routine healthcare systems and implementing prevention and control policies in the general population needs an urgent attention.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V
Subject
/ Adult
/ AIDS-Related Opportunistic Infections - epidemiology
/ Analysis
/ Blood Donors - statistics & numerical data
/ Hepatitis B virus - immunology
/ Hepatitis B virus - pathogenicity
/ Hepatitis C Antibodies - blood
/ Hepatitis Viruses - pathogenicity
/ Hepatitis, Viral, Human - epidemiology
/ Hepatitis, Viral, Human - virology
/ HIV Infections - epidemiology
/ Humans
/ Medicine
