Journal Article

The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China—recommendations from the Chinese Society of Hematology

Xu, Lanping, Huang, He, Song, Yongping, Wu, Depei, Ren, Hanyun, Sun, Zimin, Liu, Daihong, Huang, Xiaojun, Jiang, Ming, Zou, Ping, Lai, Yongrong, Liu, Kaiyan, Zhou, Daobin, Han, Mingzhe, Wang, Jianmin, Liu, Qifa, Chen, Hu, Chen, Jing, Liu, Ting

2018

Overview

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is widely used to treat malignant hematological neoplasms and non-malignant hematological disorders. Approximately, 5000 allo-HSCT procedures are performed in China annually. Substantial progress has been made in haploidentical HSCT (HID-HSCT), pre-transplantation risk stratification, and donor selection in allo-HSCT, especially after the establishment of the “Beijing Protocol” HID-HSCT system. Transplant indications for selected subgroups in low-risk leukemia or severe aplastic anemia (SAA) differ from those in the Western world. These unique systems developed by Chinese doctors may inspire the refining of global clinical practice. We reviewed the efficacy of allo-HSCT practice from available Chinese studies on behalf of the HSCT workgroup of the Chinese Society of Hematology, Chinese Medical Association and compared these studies to the consensus or guideline outside China. We summarized the consensus on routine practices of all-HSCT in China and focused on the recommendations of indications, conditioning regimen, and donor selection.

• Publisher: BioMed Central,BioMed Central Ltd,BMC
• Subject: Allogeneic hematopoietic transplantation / Anemia, Aplastic - epidemiology / Anemia, Aplastic - therapy / Cancer Research / Care and treatment / Chemotherapy / China / China - epidemiology / Conditioning regimen / Consensus / Diagnosis / Donor selection / Donor Selection - methods / Donor Selection - standards / Granulocyte colony-stimulating factor / Hematologic diseases / Hematologic Diseases - epidemiology / Hematologic Diseases - therapy / Hematology / Hematopoietic stem cell transplantation / Hematopoietic Stem Cell Transplantation - methods / Hematopoietic Stem Cell Transplantation - standards / Humans / Indication / Leukemia - epidemiology / Leukemia - therapy / Leukemia, Myelogenous, Chronic, BCR-ABL Positive - epidemiology / Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy / Leukemia, Myeloid, Acute - epidemiology / Leukemia, Myeloid, Acute - therapy / Medicine / Medicine & Public Health / Myelodysplastic Syndromes - epidemiology / Myelodysplastic Syndromes - therapy / Oncology / Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology / Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy / Review / Societies, Medical / Transplantation Conditioning - methods / Transplantation Conditioning - standards / Transplantation, Homologous - methods / Transplantation, Homologous - standards