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Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study
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Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study
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Journal Article
Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study
2024
Overview
Background
Although it is thought that prostatitis or benign prostatic hyperplasia (BPH) is related to prostate cancer (PCa), the underlying causal effects of these diseases are unclear.
Methods
We assessed the causal relationship between prostatitis or BPH and PCa using a two-sample Mendelian randomization (MR) approach. The data utilized in this study were sourced from genome-wide association study. The association of genetic variants from cohorts of prostatitis or BPH and PCa patients was determined using inverse-variance weighted and MR Egger regression techniques. The direction of chance was determined using independent genetic variants with genome-wide significance (
P
< 5 × 10
–6
). The accuracy of the results was confirmed using sensitivity analyses.
Results
MR analysis showed that BPH had a significant causal effect on PCa (Odds Ratio = 1.209, 95% Confidence Interval: 0.098–0.281,
P
= 5.079 × 10
− 5
) while prostatitis had no significant causal effect on PCa (
P
> 0.05). Additionally, the pleiotropic test and leave-one-out analysis showed the two-sample MR analyses were valid and reliable.
Conclusions
This MR study supports that BPH has a positive causal effect on PCa, while genetically predicted prostatitis has no causal effect on PCa. Nonetheless, further studies should explore the underlying biochemical mechanism and potential therapeutic targets for the prevention of these diseases.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Benign prostatic hyperplasia
/ Biomedical and Life Sciences
/ Cancer
/ Diseases
/ Genetic Predisposition to Disease
/ Genome-wide association studies
/ Genome-Wide Association Study
/ Genomes
/ Genomics
/ GWAS
/ Health Promotion and Disease Prevention
/ Humans
/ Male
/ Men
/ Mendelian Randomization Analysis
/ Oncology
/ Polymorphism, Single Nucleotide
/ Prostatic Hyperplasia - genetics
