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A review on drug-induced dry eye disease
by
Narang, Purvasha
, Kam, Ka Wai
, Di Zazzo, Antonio
, Basu, Sayan
, Jhanji, Vishal
, De Gregorio, Chiara
in
Analysis
/ Antineoplastic drugs
/ Antitumor agents
/ Care and treatment
/ Complications and side effects
/ Conjunctivitis
/ Diagnosis
/ Dosage and administration
/ drug-induced cicatrizing conjunctivitis
/ drug-induced dry eye disease
/ Dry eye syndromes
/ Dry Eye Syndromes - chemically induced
/ Dry Eye Syndromes - diagnosis
/ Dry Eye Syndromes - drug therapy
/ Exocrine glands
/ Eye diseases
/ Fibroblast growth factors
/ Growth factors
/ Homeostasis
/ Humans
/ Immune checkpoint inhibitors
/ Immunosuppressive agents
/ Inflammation
/ Lacrimal Apparatus
/ Lacrimal gland and Nasolacrimal duct
/ Meibomian Gland Dysfunction
/ Meibomian Glands - metabolism
/ Monoclonal antibodies
/ Physiology, Pathological
/ Review - Basic Sciences and Applied Research
/ Review Article - Basic Sciences and Applied Research
/ Side effects
/ Tears - metabolism
2023
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A review on drug-induced dry eye disease
by
Narang, Purvasha
, Kam, Ka Wai
, Di Zazzo, Antonio
, Basu, Sayan
, Jhanji, Vishal
, De Gregorio, Chiara
in
Analysis
/ Antineoplastic drugs
/ Antitumor agents
/ Care and treatment
/ Complications and side effects
/ Conjunctivitis
/ Diagnosis
/ Dosage and administration
/ drug-induced cicatrizing conjunctivitis
/ drug-induced dry eye disease
/ Dry eye syndromes
/ Dry Eye Syndromes - chemically induced
/ Dry Eye Syndromes - diagnosis
/ Dry Eye Syndromes - drug therapy
/ Exocrine glands
/ Eye diseases
/ Fibroblast growth factors
/ Growth factors
/ Homeostasis
/ Humans
/ Immune checkpoint inhibitors
/ Immunosuppressive agents
/ Inflammation
/ Lacrimal Apparatus
/ Lacrimal gland and Nasolacrimal duct
/ Meibomian Gland Dysfunction
/ Meibomian Glands - metabolism
/ Monoclonal antibodies
/ Physiology, Pathological
/ Review - Basic Sciences and Applied Research
/ Review Article - Basic Sciences and Applied Research
/ Side effects
/ Tears - metabolism
2023
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A review on drug-induced dry eye disease
by
Narang, Purvasha
, Kam, Ka Wai
, Di Zazzo, Antonio
, Basu, Sayan
, Jhanji, Vishal
, De Gregorio, Chiara
in
Analysis
/ Antineoplastic drugs
/ Antitumor agents
/ Care and treatment
/ Complications and side effects
/ Conjunctivitis
/ Diagnosis
/ Dosage and administration
/ drug-induced cicatrizing conjunctivitis
/ drug-induced dry eye disease
/ Dry eye syndromes
/ Dry Eye Syndromes - chemically induced
/ Dry Eye Syndromes - diagnosis
/ Dry Eye Syndromes - drug therapy
/ Exocrine glands
/ Eye diseases
/ Fibroblast growth factors
/ Growth factors
/ Homeostasis
/ Humans
/ Immune checkpoint inhibitors
/ Immunosuppressive agents
/ Inflammation
/ Lacrimal Apparatus
/ Lacrimal gland and Nasolacrimal duct
/ Meibomian Gland Dysfunction
/ Meibomian Glands - metabolism
/ Monoclonal antibodies
/ Physiology, Pathological
/ Review - Basic Sciences and Applied Research
/ Review Article - Basic Sciences and Applied Research
/ Side effects
/ Tears - metabolism
2023
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Journal Article
A review on drug-induced dry eye disease
2023
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Overview
Dry eye disease encompasses a broad range of etiologies and disease subtypes which have similar clinical manifestations. Medications can cause dry eye disease or symptoms of dryness as a side effect by either interfering with the lacrimal gland or meibomian gland function, or both, and by other mechanisms that affect the ocular surface homeostasis. This is important to know and recognize as eliminating the offending medication can reverse the symptoms and, in many cases, prevent further deterioration of the ocular surface inflammation. This review focuses on drugs like systemic isotretinoin and taxanes, which cause meibomian gland dysfunction; immune checkpoint inhibitors that cause lacrimal gland dysfunction; gliptins and topical antiglaucoma medications that cause cicatrizing conjunctivitis; and epidermal growth factor receptor inhibitors, fibroblast growth factor receptor inhibitors, and belantamab mafodotin, which cause mucosal epitheliopathy. Many of these medications, particularly the newer anticancer agents, have only recently been introduced for clinical use, and knowledge and awareness of their ocular side effects are still evolving. This review aims to update ophthalmologists on the drug-induced causes of dry eye disease or symptoms of dryness, which is avoidable by discontinuation of the incriminating agent or can be mitigated by reducing the dose or frequency of usage.
Publisher
Medknow Publications & Media Pvt Ltd,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Wolters Kluwer - Medknow,Wolters Kluwer Medknow Publications
Subject
/ Complications and side effects
/ drug-induced cicatrizing conjunctivitis
/ drug-induced dry eye disease
/ Dry Eye Syndromes - chemically induced
/ Dry Eye Syndromes - diagnosis
/ Dry Eye Syndromes - drug therapy
/ Humans
/ Immune checkpoint inhibitors
/ Lacrimal gland and Nasolacrimal duct
/ Meibomian Glands - metabolism
/ Review - Basic Sciences and Applied Research
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