Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Safety profile of autologous macrophage therapy for liver cirrhosis

by Nielsen, Mette J , McGowan, Neil W A , Moroni, Francesca , Graham, Catriona , Pass, Chloe , Turner, Marc L , Moore, Joanna K , Ritchie, Lisa , Barry, Jacqueline , Campbell, John D M , Fallowfield, Jonathan A , bes, Stuart J , Hayes, Peter C , Mitchell, Donna , Laurie, Audrey , Fraser, Alasdair R , Musa, Kishwar , Doig, Stuart , Glover, Alison , Dwyer, Benjamin J , Hargreaves, Emily , Leeming, Diana J , Bailey, Laura

in Ascites / Autografts / Cell activation / Cirrhosis / Drug dosages / Feasibility studies / Fibrosis / Leukapheresis / Liver / Liver cirrhosis / Liver diseases / Macrophages / Medicine / Regeneration / Safety / Therapy / Transfusion / Transplants & implants

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Safety profile of autologous macrophage therapy for liver cirrhosis

2019

Confirm

Do you wish to request the book?

Safety profile of autologous macrophage therapy for liver cirrhosis

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Safety profile of autologous macrophage therapy for liver cirrhosis

Nielsen, Mette J,

McGowan, Neil W A,

Moroni, Francesca,

Graham, Catriona,

Pass, Chloe,

Turner, Marc L,

Moore, Joanna K,

Ritchie, Lisa,

Barry, Jacqueline,

Campbell, John D M,

Fallowfield, Jonathan A,

bes, Stuart J,

Hayes, Peter C,

Mitchell, Donna,

Laurie, Audrey,

Fraser, Alasdair R,

Musa, Kishwar,

Doig, Stuart,

Glover, Alison,

Dwyer, Benjamin J,

Hargreaves, Emily,

Leeming, Diana J,

Bailey, Laura

2019

Overview

Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We conducted a first-in-human, phase 1 dose-escalation trial of autologous macrophage therapy in nine adults with cirrhosis and a Model for End-Stage Liver Disease (MELD) score of 10–16 (ISRCTN 10368050). Groups of three participants received a single peripheral infusion of 107, 108 or up to 109 cells. Leukapheresis and macrophage infusion were well tolerated with no transfusion reactions, dose-limiting toxicities or macrophage activation syndrome. All participants were alive and transplant-free at one year, with only one clinical event recorded, the occurrence of minimal ascites. The primary outcomes of safety and feasibility were met. This study informs and provides a rationale for efficacy studies in cirrhosis and other fibrotic diseases.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group

Subject

/ Feasibility studies

/ Fibrosis