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Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

by Schjesvold Fredrik , Durie, Brian , Kaiser, Martin , Moreau, Philippe , Miguel Jesús San , Wirk Baldeep , Rosiñol Laura , Fernández de Larrea Carlos , Mateos, Maria Victoria , Engelhardt, Monika , Kyle, Robert , Gonsalves, Wilson , Ocio Enrique , Hayden, Patrick , Badros Ashraf , Sonneveld Pieter , Usmani Saad , Caers Jo , Paiva, Bruno , Merlini Giampaolo , Gahrton Gösta , Lentzch Suzanne , Tuchman Sascha , Goldschmidt Hartmut , Vincent, Rajkumar S , Bladé Joan , Einsele Hermann , Musto Pellegrino , Garderet Laurent

in Leukemia / Multiple myeloma / Plasma

2021

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Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

in Leukemia / Multiple myeloma / Plasma

2021

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Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

in Leukemia / Multiple myeloma / Plasma

2021

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Journal Article

Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

Schjesvold Fredrik,

Durie, Brian,

Kaiser, Martin,

Moreau, Philippe,

Miguel Jesús San,

Wirk Baldeep,

Rosiñol Laura,

Fernández de Larrea Carlos,

Mateos, Maria Victoria,

Engelhardt, Monika,

Kyle, Robert,

Gonsalves, Wilson,

Ocio Enrique,

Hayden, Patrick,

Badros Ashraf,

Sonneveld Pieter,

Usmani Saad,

Caers Jo,

Paiva, Bruno,

Merlini Giampaolo,

Gahrton Gösta,

Lentzch Suzanne,

Tuchman Sascha,

Goldschmidt Hartmut,

Vincent, Rajkumar S,

Bladé Joan,

Einsele Hermann,

Musto Pellegrino,

Garderet Laurent

2021

Overview

Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL according to the presence of circulating plasma cells in patients otherwise meeting diagnostic criteria of multiple myeloma. We could identify two retrospective series where the question about what number of circulating plasma cells in peripheral blood should be used for defining PCL. The presence of ≥5% circulating plasma cells in patients with MM had a similar adverse prognostic impact as the previously defined PCL. Therefore, PCL should be defined by the presence of 5% or more circulating plasma cells in peripheral blood smears in patients otherwise diagnosed with symptomatic multiple myeloma.

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Publisher

Springer Nature B.V

Subject

Leukemia

/ Multiple myeloma

/ Plasma