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Mathematical model for rod outer segment dynamics during retinal detachment
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Mathematical model for rod outer segment dynamics during retinal detachment
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Journal Article
Mathematical model for rod outer segment dynamics during retinal detachment
2024
Overview
Retinal detachment (RD) is the separation of the neural layer from the retinal pigmented epithelium thereby preventing the supply of nutrients to the cells within the neural layer of the retina. In vertebrates, primary photoreceptor cells consisting of rods and cones undergo daily renewal of their outer segment through the addition of disc-like structures and shedding of these discs at their distal end. When the retina detaches, the outer segment of these cells begins to degenerate and, if surgical procedures for reattachment are not done promptly, the cells can die and lead to blindness. The precise effect of RD on the renewal process is not well understood. Additionally, a time frame within which reattachment of the retina can restore proper photoreceptor cell function is not known. Focusing on rod cells, we propose a mathematical model to clarify the influence of retinal detachment on the renewal process. Our model simulation and analysis suggest that RD stops or significantly reduces the formation of new discs and that an alternative removal mechanism is needed to explain the observed degeneration during RD. Sensitivity analysis of our model parameters points to the disc removal rate as the key regulator of the critical time within which retinal reattachment can restore proper photoreceptor cell function.
Publisher
Public Library of Science
Subject
/ Animals
/ Cones
/ Humans
/ Medicine and Health Sciences
/ Research and Analysis Methods
/ Retina
/ Retinal Detachment - pathology
/ Retinal Detachment - surgery
/ Retinal Rod Photoreceptor Cells - pathology
/ Retinal Rod Photoreceptor Cells - physiology
/ Rod Cell Outer Segment - metabolism
/ Rod Cell Outer Segment - physiology
/ Segments
