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Journal Article
Current Concepts in Antifungal Pharmacology
2011
Overview
The introduction of new antifungal agents (eg, echinocandins, second-generation triazoles) in the past decade has transformed the management of invasive mycoses to the point that drug toxicity is no longer the major limiting factor in treatment. Yet, many of these newer antifungal agents have important limitations in their spectrum of activity, pharmacokinetics, and unique predisposition for pharmacokinetic drug-drug interactions and unusual toxicities associated with long-term use. This article reviews key pharmacological aspects of systemic antifungal agents as well as evolving strategies, such as pharmacokinetic-pharmacodynamic optimization and therapeutic drug monitoring, to improve the safety and efficacy of systemic antifungal therapy.
Publisher
Elsevier Inc,Mayo Foundation,Elsevier, Inc,Elsevier Limited,Mayo Foundation for Medical Education and Research
Subject
Antibiotics. Antiinfectious agents. Antiparasitic agents
/ Antifungal Agents - adverse effects
/ Antifungal Agents - pharmacokinetics
/ Antifungal Agents - pharmacology
/ Antifungal Agents - therapeutic use
/ Biological and medical sciences
/ Drug Resistance, Multiple, Fungal
/ Humans
/ Mycoses
