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Journal Article
RNA polymerase is poised for activation across the genome
2007
Overview
Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter
1
, followed by initiation of RNA synthesis and the transition to productive elongation
2
,
3
,
4
. In many cases, recruitment of RNA polymerase II (Pol II) to a promoter is necessary and sufficient for activation of genes. However, there are a few notable exceptions to this paradigm, including heat shock genes and several proto-oncogenes, whose expression is attenuated by regulated stalling of polymerase elongation within the promoter-proximal region
5
,
6
,
7
,
8
,
9
,
10
,
11
,
12
,
13
. To determine the importance of polymerase stalling for transcription regulation, we carried out a genome-wide search for
Drosophila melanogaster
genes with Pol II stalled within the promoter-proximal region. Our data show that stalling is widespread, occurring at hundreds of genes that respond to stimuli and developmental signals. This finding indicates a role for regulation of polymerase elongation in the transcriptional responses to dynamic environmental and developmental cues.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Animals
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Chromatin Immunoprecipitation
/ Enzymes
/ Fundamental and applied biological sciences. Psychology
/ Genes
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genomics
/ Insects
/ letter
/ RNA
