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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
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Journal Article
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
2011
Overview
The successful treatment of certain autoimmune conditions with the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.
Publisher
American Society for Clinical Investigation
Subject
/ Antibodies, Monoclonal - immunology
/ Antibodies, Monoclonal - therapeutic use
/ Antibodies, Monoclonal, Humanized
/ Autoimmune Diseases - drug therapy
/ Autoimmune Diseases - immunology
/ Cellular signal transduction
/ Cytokine Receptor gp130 - immunology
/ Humans
/ Liver
/ Receptors, Interleukin-6 - genetics
/ Receptors, Interleukin-6 - immunology
