Journal Article

Annexin A1 and the Resolution of Inflammation: Modulation of Neutrophil Recruitment, Apoptosis, and Clearance

Sugimoto, Michelle Amantéa, Sousa, Lirlândia Pires, Vago, Juliana Priscila, Teixeira, Mauro Martins

2016

Overview

Neutrophils (also named polymorphonuclear leukocytes or PMN) are essential components of the immune system, rapidly recruited to sites of inflammation, providing the first line of defense against invading pathogens. Since neutrophils can also cause tissue damage, their fine-tuned regulation at the inflammatory site is required for proper resolution of inflammation. Annexin A1 (AnxA1), also known as lipocortin-1, is an endogenous glucocorticoid-regulated protein, which is able to counterregulate the inflammatory events restoring homeostasis. AnxA1 and its mimetic peptides inhibit neutrophil tissue accumulation by reducing leukocyte infiltration and activating neutrophil apoptosis. AnxA1 also promotes monocyte recruitment and clearance of apoptotic leukocytes by macrophages. More recently, some evidence has suggested the ability of AnxA1 to induce macrophage reprogramming toward a resolving phenotype, resulting in reduced production of proinflammatory cytokines and increased release of immunosuppressive and proresolving molecules. The combination of these mechanisms results in an effective resolution of inflammation, pointing to AnxA1 as a promising tool for the development of new therapeutic strategies to treat inflammatory diseases.

• Publisher: Hindawi Publishing Corporation,John Wiley & Sons, Inc,Wiley
• Subject: Annexin A1 - genetics / Annexin A1 - immunology / Anti-Inflammatory Agents, Non-Steroidal - therapeutic use / Apoptosis / Apoptosis - drug effects / Cell adhesion & migration / Cytokines / Cytokines - genetics / Cytokines - immunology / Gene Expression Regulation / Genotype & phenotype / Growth factors / Homeostasis / Humans / Immunology / Inflammation / Inflammation - drug therapy / Inflammation - genetics / Inflammation - immunology / Inflammation - pathology / Inflammatory diseases / Kinases / Macrophages - drug effects / Macrophages - immunology / Macrophages - pathology / Monocytes - drug effects / Monocytes - immunology / Monocytes - pathology / Neutrophil Infiltration - drug effects / Neutrophils / Neutrophils - drug effects / Neutrophils - immunology / Neutrophils - pathology / Peptides / Peptides - therapeutic use / Peptidomimetics - therapeutic use / Phagocytosis - drug effects / Physiology / Proteins / Recruitment / Review / Rodents / Signal Transduction / Tumor necrosis factor-TNF