Journal Article

Criticality in probabilistic models of spreading dynamics in brain networks: Epileptic seizures

Moosavi, S Amin, Truccolo, Wilson

2023

Overview

The spread of seizures across brain networks is the main impairing factor, often leading to loss-of-consciousness, in people with epilepsy. Despite advances in recording and modeling brain activity, uncovering the nature of seizure spreading dynamics remains an important challenge to understanding and treating pharmacologically resistant epilepsy. To address this challenge, we introduce a new probabilistic model that captures the spreading dynamics in patient-specific complex networks. Network connectivity and interaction time delays between brain areas were estimated from white-matter tractography. The model’s computational tractability allows it to play an important complementary role to more detailed models of seizure dynamics. We illustrate model fitting and predictive performance in the context of patient-specific Epileptor networks. We derive the phase diagram of spread size (order parameter) as a function of brain excitability and global connectivity strength, for different patient-specific networks. Phase diagrams allow the prediction of whether a seizure will spread depending on excitability and connectivity strength. In addition, model simulations predict the temporal order of seizure spread across network nodes. Furthermore, we show that the order parameter can exhibit both discontinuous and continuous (critical) phase transitions as neural excitability and connectivity strength are varied. Existence of a critical point, where response functions and fluctuations in spread size show power-law divergence with respect to control parameters, is supported by mean-field approximations and finite-size scaling analyses. Notably, the critical point separates two distinct regimes of spreading dynamics characterized by unimodal and bimodal spread-size distributions. Our study sheds new light on the nature of phase transitions and fluctuations in seizure spreading dynamics. We expect it to play an important role in the development of closed-loop stimulation approaches for preventing seizure spread in pharmacologically resistant epilepsy. Our findings may also be of interest to related models of spreading dynamics in epidemiology, biology, finance, and statistical physics.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Analysis / Biology and Life Sciences / Brain / Closed loops / Computational neuroscience / Computer and Information Sciences / Consciousness / Convulsions & seizures / Critical point / Divergence / Dynamics / Electroencephalography - methods / Epidemiology / Epilepsy / Equilibrium / Excitability / Fluctuations / Health aspects / Humans / Learning models (Stochastic processes) / Mathematical models / Medicine and Health Sciences / Models, Statistical / Networks / Neural circuitry / Neural networks / Order parameters / Performance prediction / Pharmacology / Phase diagrams / Phase transitions / Physical Sciences / Probabilistic models / Research and Analysis Methods / Response functions / Seizures / Seizures (Medicine) / Simulation / Simulation methods / Spreading / Statistical analysis / Substantia alba / Temporal variations / Timing