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Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes

by Sandvig, Kirsten , Fromm, Bastian , Llorente, Alicia , Bajo-Santos, Cristina , Lorenz, Susanne , Berge, Viktor , Rodríguez, Marta , Linē, Aija , Hessvik, Nina P.

in Adult / Aged / Analysis / Biological markers / Biomarkers / Biomedical and Life Sciences / Biomedicine / Biopsy / Cancer Research / Case-Control Studies / Diagnosis / Exosomes / Exosomes - genetics / Extracellular vesicles / Gene expression / Genetic aspects / Genomes / High-Throughput Nucleotide Sequencing / Humans / Letter to the Editor / Male / MicroRNA / MicroRNAs / MicroRNAs - genetics / MicroRNAs - isolation & purification / MicroRNAs - urine / Microvesicles / Middle Aged / miRNA / Neoplasm Grading / Neoplasm Staging / noncodingRNA / Oncology / Patients / Physiological aspects / Prostate cancer / Prostatic Neoplasms - diagnosis / Prostatic Neoplasms - genetics / Prostatic Neoplasms - urine / Reproducibility of Results / Ribonucleic acid / RNA / ROC Curve / Tumors / Urine

2017

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Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes

by Sandvig, Kirsten , Fromm, Bastian , Llorente, Alicia , Bajo-Santos, Cristina , Lorenz, Susanne , Berge, Viktor , Rodríguez, Marta , Linē, Aija , Hessvik, Nina P.

2017

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Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes

by Sandvig, Kirsten , Fromm, Bastian , Llorente, Alicia , Bajo-Santos, Cristina , Lorenz, Susanne , Berge, Viktor , Rodríguez, Marta , Linē, Aija , Hessvik, Nina P.

2017

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Journal Article

Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes

Sandvig, Kirsten,

Fromm, Bastian,

Llorente, Alicia,

Bajo-Santos, Cristina,

Lorenz, Susanne,

Berge, Viktor,

Rodríguez, Marta,

Linē, Aija,

Hessvik, Nina P.

2017

Overview

The aim of this study was to identify microRNAs in urinary exosomes that are differently expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted from urinary exosomes from 20 prostate cancer patients and 9 healthy males and the microRNAs were analyzed by next generation sequencing. Interestingly, 5 microRNAs – miR-196a-5p, miR-34a-5p, miR-143-3p, miR-501-3p and miR-92a-1-5p – were significantly downregulated in exosomes from prostate cancer patients. Furthermore, RT-qPCR analysis of an independent cohort of 28 prostate cancer patients and 19 healthy males confirmed that miR-196a-5p and miR-501-3p were downregulated in prostate cancer samples. These results suggest that specific microRNAs in urinary exosomes might serve as non-invasive biomarkers for prostate cancer. In particular, miR-196a-5p and miR-501-3p are promising biomarkers that need to be further studied in large patient cohorts.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

/ Aged

/ Biomedical and Life Sciences

/ Biomedicine