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Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

by Kumar, Hemanth , Gerona, Roy , Gupte, Nikhil , Gandhi, Monica , Khwaja, Sultanat , Dooley, Kelly E. , Bharadwaj, Renu , Kagal, Anju , Koli, Hari , Gupta, Amita , Ramachandran, Geetha , Bacchetti, Peter , Mave, Vidya , Wen, Anita , Kinikar, Aarti , Nimkar, Smita

in Antitubercular Agents - analysis / Antitubercular Agents - blood / Antitubercular Agents - therapeutic use / Area Under Curve / Biology and Life Sciences / Child, Preschool / Complications and side effects / Dosage and administration / Drug therapy / Humans / Isoniazid / Isoniazid - analysis / Isoniazid - blood / Isoniazid - therapeutic use / Medicine and Health Sciences / Patient outcomes / Prospective Studies / Tuberculosis / Tuberculosis - drug therapy

2017

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Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

2017

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Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

2017

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Journal Article

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis

Kumar, Hemanth,

Gerona, Roy,

Gupte, Nikhil,

Gandhi, Monica,

Khwaja, Sultanat,

Dooley, Kelly E.,

Bharadwaj, Renu,

Kagal, Anju,

Koli, Hari,

Gupta, Amita,

Ramachandran, Geetha,

Bacchetti, Peter,

Mave, Vidya,

Wen, Anita,

Kinikar, Aarti,

Nimkar, Smita

2017

Overview

We measured hair and plasma concentrations of isoniazid among sixteen children with tuberculosis who underwent personal or video-assisted directly observed therapy and thus had 100% adherence. This study therefore defined typical isoniazid exposure parameters after two months of treatment among fully-adherent patients in both hair and plasma (plasma area under the concentration-time curve, AUC, estimated using pharmacokinetic data collected 0, 2, 4, and 6 hours after drug administration). We found that INH levels in hair among highly-adherent individuals did not correlate well with plasma AUC or trough concentrations, suggesting that each measure may provide incremental and complementary information regarding drug exposure in the context of TB treatment.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Antitubercular Agents - analysis

/ Antitubercular Agents - blood

/ Antitubercular Agents - therapeutic use

/ Area Under Curve

/ Biology and Life Sciences

/ Child, Preschool

/ Complications and side effects