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Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

by Gelfand, Mikhail S. , Grafskaia, Ekaterina N. , Govorun, Vadim M. , Babenko, Vladislav V. , Kovalchuk, Sergey I. , Kurdyumov, Alexey S. , Matyushkina, Daria S. , Vinogradov, Dmitriy V. , Kostryukova, Elena S. , Trukhan, Vladimir M. , Rakitina, Daria V. , Baskova, Isolda P. , Lazarev, Vassili N. , Schiöth, Helgi B. , Pobeguts, Olga V. , Manuvera, Valentin A. , Butenko, Ivan O. , Anikanov, Nickolay A. , Nikitina, Anastasia S. , Manolov, Alexander I. , Zgoda, Victor G. , Shirokov, Dmitriy A. , Podgorny, Oleg V. , Kasianov, Artem S.

in Analysis / Animal Genetics and Genomics / Animals / Annotations / Anticoagulants / Anticoagulants - metabolism / Biomedical and Life Sciences / Blood / Datasets / Gene expression / Gene Expression Profiling / Gene Expression Regulation / Gene sequencing / Genes / Genetic aspects / Genetics / Genome / Genomes / Genomics / Haematophagy / Hirudo medicinalis / Hirudo medicinalis - genetics / Hirudo medicinalis - metabolism / Homology / Leech H / Leech H. medicinalis / Leeches / Leeches - classification / Leeches - genetics / Leeches - metabolism / Life Sciences / medicinalis / Microarrays / Microbial Genetics and Genomics / Multicellular invertebrate genomics / Plant Genetics and Genomics / Proteins / Proteomics / Research Article / Ribonucleic acid / RNA / Saliva - metabolism / Salivary Proteins and Peptides - genetics / Salivary Proteins and Peptides - metabolism / Systems biology

2020

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Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

2020

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Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

2020

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Journal Article

Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

Gelfand, Mikhail S.,

Grafskaia, Ekaterina N.,

Govorun, Vadim M.,

Babenko, Vladislav V.,

Kovalchuk, Sergey I.,

Kurdyumov, Alexey S.,

Matyushkina, Daria S.,

Vinogradov, Dmitriy V.,

Kostryukova, Elena S.,

Trukhan, Vladimir M.,

Rakitina, Daria V.,

Baskova, Isolda P.,

Lazarev, Vassili N.,

Schiöth, Helgi B.,

Pobeguts, Olga V.,

Manuvera, Valentin A.,

Butenko, Ivan O.,

Anikanov, Nickolay A.,

Nikitina, Anastasia S.,

Manolov, Alexander I.,

Zgoda, Victor G.,

Shirokov, Dmitriy A.,

Podgorny, Oleg V.,

Kasianov, Artem S.

2020

Overview

Background Salivary cell secretion (SCS) plays a critical role in blood feeding by medicinal leeches, making them of use for certain medical purposes even today. Results We annotated the Hirudo medicinalis genome and performed RNA-seq on salivary cells isolated from three closely related leech species, H. medicinalis, Hirudo orientalis , and Hirudo verbana . Differential expression analysis verified by proteomics identified salivary cell-specific gene expression, many of which encode previously unknown salivary components. However, the genes encoding known anticoagulants have been found to be expressed not only in salivary cells. The function-related analysis of the unique salivary cell genes enabled an update of the concept of interactions between salivary proteins and components of haemostasis. Conclusions Here we report a genome draft of Hirudo medicinalis and describe identification of novel salivary proteins and new homologs of genes encoding known anticoagulants in transcriptomes of three medicinal leech species. Our data provide new insights in genetics of blood-feeding lifestyle in leeches.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

Analysis

/ Animal Genetics and Genomics

/ Animals

/ Annotations

/ Anticoagulants

/ Anticoagulants - metabolism

/ Biomedical and Life Sciences