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Computational Mass Spectrometry–Based Proteomics
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Journal Article
Computational Mass Spectrometry–Based Proteomics
2011
Overview
The distances between the MS/MS peaks are used to infer the amino acid sequence of the parent MS peak. Since abundant MS1 peaks are more likely to be selected for fragmentation, relative peptide quantification can also be achieved by counting the number of identified MS/MS spectra. The moderate correlation of transcript and protein abundance indicates a major role of post-translational regulation in the activity of the cell. [...]the best functional insight can be obtained by combining measurements across technologies, and searching for broader groups of genes, proteins, and metabolites forming regulatory relationships [86], [87]. To date, only 65% of all predicted human proteins have been reliably observed by mass spectrometry [90]. [...]future experimental developments will focus on improving the sensitivity, reproducibility, and comprehensiveness of protein identifications, and the sensitivity and accuracy of quantification.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
