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CD317+ MSCs expanded with chemically defined media have enhanced immunological anti-inflammatory activities
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CD317+ MSCs expanded with chemically defined media have enhanced immunological anti-inflammatory activities
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Journal Article
CD317+ MSCs expanded with chemically defined media have enhanced immunological anti-inflammatory activities
2024
Overview
Background
Although both preclinical and clinical studies have shown the great application potential of MSCs (mesenchymal stem/stromal cells) in treating many kinds of diseases, therapeutic inconsistency resulting from cell heterogeneity is the major stumbling block to their clinical applications. Cell population diversity and batch variation in the cell expansion medium are two major inducers of MSC heterogeneity.
Methods
Cell population diversity was investigated through single-cell RNA sequencing analysis of human MSCs derived from the umbilical cord and expanded with fully chemically defined medium in the current study. Then, the MSC subpopulation with enhanced anti-inflammatory effects was studied in vitro and in vivo.
Results
Our data showed that MSCs contain different populations with different functions, including subpopulations with enhanced functions of exosome secretion, extracellular matrix modification and responses to stimuli (regeneration and immune response). Among them, CD317
+
MSCs have improved differentiation capabilities and enhanced immune suppression activities. Underlying mechanism studies showed that higher levels of TSG6 confer enhanced anti-inflammatory functions of CD317
+
MSCs.
Conclusions
Thus, CD317
+
MSCs might be a promising candidate for treating immunological disorder-related diseases.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
Anti-Inflammatory Agents - pharmacology
/ Biomedical and Life Sciences
/ Biomedical Engineering and Bioengineering
/ CD317
/ Ethics
/ Ethylenediaminetetraacetic acid
/ Genomics
/ Humans
/ Mesenchymal Stem Cell Transplantation
/ Mesenchymal stem/stromal cells
/ MSCs
/ Regenerative Medicine/Tissue Engineering
/ RNA
/ Scientific equipment and supplies industry
/ Software
/ TSG6
/ Urology
