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Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer
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Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer
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Journal Article
Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer
2019
Overview
Microsatellite instability determines whether patients with gastrointestinal cancer respond exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested for MSI, because this requires additional genetic or immunohistochemical tests. Here we show that deep residual learning can predict MSI directly from H&E histology, which is ubiquitously available. This approach has the potential to provide immunotherapy to a much broader subset of patients with gastrointestinal cancer.A deep residual learning framework identifies microsatellite instability in histology slides from patients with cancer and can be used to guide immunotherapy.
Publisher
Nature Publishing Group
Subject
