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Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus
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Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus
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Journal Article
Blocking heterochromatin spreading constrains cohesin binding at a yeast heterochromatic locus
2026
Overview
Cohesin mediates central features of chromosome architecture. The protein complex governs sister chromatid cohesion and organizes genomes into loops and domains. In budding yeast, cohesin accumulates at discrete sites on chromosome arms, as well as at domains of heterochromatin. The molecular basis for the distribution at these sites is not yet resolved, although the heterochromatin protein Sir2 has been implicated. If cohesin were to bind a recurring feature of heterochromatin, then size of the cohesin domain would match the size of the heterochromatin domain. To test this hypothesis, the span of heterochromatin at the HMR silent mating-type locus was truncated with artificial barrier elements built from bacterial DNA binding proteins. We found that the most effective barrier reduced the footprint of Sir3 and Smc3, representative components of yeast heterochromatin and cohesin. These results show that reducing the span of heterochromatin at HMR constrains the size of the cohesin bound domain.
Publisher
Public Library of Science,PLOS,Public Library of Science (PLoS)
Subject
/ Binding
/ Cell Cycle Proteins - genetics
/ Cell Cycle Proteins - metabolism
/ Chromosomal Proteins, Non-Histone - genetics
/ Chromosomal Proteins, Non-Histone - metabolism
/ Cohesin
/ Cohesins
/ Cohesion
/ Ethylenediaminetetraacetic acid
/ Genes
/ Genomes
/ Genomics
/ Heterochromatin - metabolism
/ Plasmids
/ Proteins
/ Research and Analysis Methods
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae - metabolism
/ Saccharomyces cerevisiae Proteins - genetics
/ Saccharomyces cerevisiae Proteins - metabolism
/ Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics
/ Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
/ Yeast
