Asset Details
Do you wish to reserve the book?
Nonlinear elasticity in biological gels
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Nonlinear elasticity in biological gels
Do you wish to request the book?
Nonlinear elasticity in biological gels
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Nonlinear elasticity in biological gels
2005
Overview
The mechanical properties of soft biological tissues are essential to their physiological function and cannot easily be duplicated by synthetic materials. Unlike simple polymer gels, many biological materials--including blood vessels, mesentery tissue, lung parenchyma, cornea and blood clots--stiffen as they are strained, thereby preventing large deformations that could threaten tissue integrity. The molecular structures and design principles responsible for this nonlinear elasticity are unknown. Here we report a molecular theory that accounts for strain-stiffening in a range of molecularly distinct gels formed from cytoskeletal and extracellular proteins and that reveals universal stress-strain relations at low to intermediate strains. The input to this theory is the force-extension curve for individual semi-flexible filaments and the assumptions that biological networks composed of these filaments are homogeneous, isotropic, and that they strain uniformly. This theory shows that systems of filamentous proteins arranged in an open crosslinked mesh invariably stiffen at low strains without requiring a specific architecture or multiple elements with different intrinsic stiffness.
Publisher
Nature Publishing,Nature Publishing Group
Subject
Biological and medical sciences
/ Classical and quantum physics: mechanics and fields
/ Classical mechanics of continuous media: general mathematical aspects
/ Elasticity, plasticity: general mathematical aspects
/ Entropy
/ Exact sciences and technology
/ Fundamental and applied biological sciences. Psychology
/ Gels
/ Intermediate Filaments - chemistry
/ Physics
/ Polymers
/ Q1
/ Theory
/ Tissues
