Journal Article

Controlling stem cell fate using cold atmospheric plasma

Al-Rubeai, Mohamed, Fang, Yin, Tan, Fei, Zhu, Liwei

2020

Overview

The stem cell is the foundation of regenerative medicine and tissue engineering. Regulating specific stem cell fate, such as cell attachment, proliferation, differentiation, and even death, undergoes continuous development. Cold atmospheric plasma (CAP), the core technology of plasma medicine, is attracting tremendous attention due to its ability and versatility to manipulate various types of cells, including stem cells. Specifically, the direct and indirect applications of CAP in controlling cell fate are best exemplified by upfront irradiation of the stem cells and modification of the stem cell niche, respectively. This review will describe the recent advances in various CAP strategies, both direct and indirect, and their influence on the fate of healthy and cancer stem cells. Particular emphasis will be placed on the mechanism of connecting the physical and chemical cues carried by the plasma and biological changes presented by the cells, especially at the transcriptomic level. The ultimate goal is to exploit CAP’s potential in regenerative medicine.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adhesion / Atmospheric plasma / Biomedical and Life Sciences / Biomedical Engineering and Bioengineering / Cell adhesion / Cell attachment / Cell Biology / Cell culture / Cell death / Cell differentiation / Cell fate / Cell growth / Cell proliferation / Charged particles / Chemical stimuli / Contact angle / Life Sciences / Medicine / Nitrogen / Plasma / Plasma medicine / Radiation / Regenerative medicine / Regenerative Medicine/Tissue Engineering / Review / Stem cell / Stem cell research / Stem Cells / Surface chemistry / Technology application / Tissue engineering / Topography / Transplants & implants