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Centrosome clustering and chromosomal (in)stability: A matter of life and death
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Centrosome clustering and chromosomal (in)stability: A matter of life and death
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Journal Article
Centrosome clustering and chromosomal (in)stability: A matter of life and death
2011
Overview
Centrosome abnormalities occur commonly in cancer, and contribute to chromosomal instability and tumorigenesis. New evidence on a phylogenetically conserved mechanism termed ‘centrosomal clustering’ provides exciting insights into how cells with supernumerary centrosomes adapt to avoid lethal multipolar divisions. Here, we highlight the emerging molecular basis of centrosome clustering, and its impact on asymmetric divisions of stem cells, chromosomal (in)stability and malignant transformation. Finally, pharmacological inhibition of centrosome clustering promises to selectively target tumor cells.
► Centrosome abnormalities occur commonly in cancer. ► Centrosome clustering enables cells with extra centrosomes to divide successfully. ► We discuss the molecular basis of centrosome clustering and its biological roles. ► Clustering impacts on stem cell division, chromosomal stability and tumorigenesis. ► Inhibition of centrosome clustering promises to selectively target tumor cells.
Publisher
Elsevier B.V,John Wiley & Sons, Inc,John Wiley and Sons Inc,Wiley
Subject
