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A common genetic risk factor for colorectal and prostate cancer
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A common genetic risk factor for colorectal and prostate cancer
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Journal Article
A common genetic risk factor for colorectal and prostate cancer
2007
Overview
Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22;
P
= 4.4 × 10
−6
) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Colorectal Neoplasms - genetics
/ Fundamental and applied biological sciences. Psychology
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Genetic Predisposition to Disease
/ Genetics
/ Genetics of eukaryotes. Biological and molecular evolution
/ Humans
/ Male
/ Nephrology. Urinary tract diseases
/ Polymorphism, Single Nucleotide
/ Prostatic Neoplasms - genetics
/ Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
/ Tumors
