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Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis
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Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis
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Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis
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Journal Article
Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis
2010
Overview
Background
The aim of this study was to isolate and identify the antifungal compounds from the extracts of
Schinus terebinthifolius
(Anacardiaceae) against clinical isolates of the pathogenic fungus
Paracoccidioides brasiliensis
.
Methods
The hexane and dichlomethane fractions from leaves and stems of
S. terebinthifolius
were fractionated using several chromatography techniques to afford four compounds.
Results
The compounds isolated from
S. terebinthifolius
were identified as schinol (
1
), a new biphenyl compound, namely, 4'-ethyl-4-methyl-2,2',6,6'-tetrahydroxy[1,1'-biphenyl]-4,4'-dicarboxylate (
2
), quercetin (
3
), and kaempferol (
4
). Compounds
1
and
2
were active against different strains of
P. brasiliensis
, showing a minimal inhibitory concentration value against the isolate Pb B339 of 15.6 μg/ml. The isolate Pb 1578 was more sensitive to compound
1
with a MIC value of 7.5 μg/ml. Schinol presented synergistic effect only when combined with itraconazole. The compounds isolated from S.
terebinthifolius
were not able to inhibit cell wall synthesis or assembly using the sorbitol assay.
Conclusion
This work reveals for the first time the occurrence of compound
2
and discloses activity of compounds
1
and
2
against several clinical isolates of
P. brasiliensi
s. These results justify further studies to clarify the mechanisms of action of these compounds.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Antifungal Agents - isolation & purification
/ Antifungal Agents - pharmacology
/ Biomedical and Life Sciences
/ Biphenyl
/ Biphenyl Compounds - isolation & purification
/ Biphenyl Compounds - pharmacology
/ Leaves
/ Microbial Genetics and Genomics
/ Minimum inhibitory concentration
/ n-Hexane
/ NMR
/ Paracoccidioides - drug effects
/ Paracoccidioides brasiliensis
/ Plant Extracts - pharmacology
/ Sorbitol
