Asset Details
Do you wish to reserve the book?
Plasma Gelsolin Depletion and Circulating Actin in Sepsis—A Pilot Study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Plasma Gelsolin Depletion and Circulating Actin in Sepsis—A Pilot Study
Do you wish to request the book?
Plasma Gelsolin Depletion and Circulating Actin in Sepsis—A Pilot Study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Plasma Gelsolin Depletion and Circulating Actin in Sepsis—A Pilot Study
2008
Overview
Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in septic patients and animals. We hypothesized that the extent of pGSN reduction correlates with outcomes of septic patients and that circulating actin is a manifestation of sepsis.
We assayed pGSN in plasma samples from non-surgical septic patients identified from a pre-existing database which prospectively enrolled patients admitted to adult intensive care units at an academic hospital. We identified 21 non-surgical septic patients for the study. Actinemia was detected in 17 of the 21 patients, suggesting actin released into circulation from injured tissues is a manifestation of sepsis. Furthermore, we documented the depletion of pGSN in human clinical sepsis, and that the survivors had significantly higher pGSN levels than the non-survivors (163+/-47 mg/L vs. 89+/-48 mg/L, p = 0.01). pGSN levels were more strongly predictive of 28-day mortality than APACHE III scores. For every quartile reduction in pGSN, the odds of death increased 3.4-fold.
We conclude that circulating actin and pGSN deficiency are associated with early sepsis. The degree of pGSN deficiency correlates with sepsis mortality. Reversing pGSN deficiency may be an effective treatment for sepsis.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ APACHE
/ Critical Care and Emergency Medicine
/ Critical Care and Emergency Medicine/Sepsis and Multiple Organ Failure
/ Gelsolin
/ Hostages
/ Humans
/ Immunology/Cellular Microbiology and Pathogenesis
/ Multiple organ dysfunction syndrome
/ Patients
/ Proteins
/ Rodents
/ Sepsis
/ Surgery
/ Tissues
/ Trauma
