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The Spatial Organization of DNA Virus Genomes in the Nucleus
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Journal Article
The Spatial Organization of DNA Virus Genomes in the Nucleus
2013
Overview
PML NBs are also of substantial size (of the order of 1 µm diameter), but while the structures themselves have limited mobility, the component proteins undergo rapid exchange with the general nucleoplasm [6]. [...]an alternative explanation of viral genome-PML NB association is that it occurs not because either entity migrates through the nucleoplasm, but because new PML NBs are formed at the sites of the viral genomes due to the deposition of PML NB protein molecules. [...]the current information is consistent with the hypothesis that entry of DNA virus genomes into the nucleus stimulates a cellular response that leads to the accumulation of PML NB proteins, and probably other restrictive proteins yet to be identified, in close association with the viral genomes.
Publisher
Public Library of Science,Public Library of Science (PLoS)
