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Advancing the understanding of autism disease mechanisms through genetics
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Journal Article
Advancing the understanding of autism disease mechanisms through genetics
2016
Overview
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has fueled remarkable advances in our understanding of its potential neurobiological mechanisms. Yet, at the same time, these findings highlight extraordinary causal diversity and complexity at many levels ranging from molecules to circuits and emphasize the gaps in our current knowledge. Here we review current understanding of the genetic architecture of ASD and integrate genetic evidence, neuropathology and studies in model systems with how they inform mechanistic models of ASD pathophysiology. Despite the challenges, these advances provide a solid foundation for the development of rational, targeted molecular therapies.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Autism
/ Autism Spectrum Disorder - genetics
/ Autism Spectrum Disorder - pathology
/ Autism Spectrum Disorder - therapy
/ Child Development Disorders, Pervasive - genetics
/ Child Development Disorders, Pervasive - pathology
/ Child Development Disorders, Pervasive - therapy
/ Etiology
/ Genetic Predisposition to Disease
/ Genetics
/ Genomics
/ Humans
