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Lipids and atrial fibrillation: New insights into a paradox
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Journal Article
Lipids and atrial fibrillation: New insights into a paradox
2022
Overview
Abbreviations:: AF, atrial fibrillation; CAD, coronary artery disease; CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; HF, heart failure; HR, hazard ratio; ICD, International Classification of Diseases; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride Provenance: Commissioned; not externally peer reviewed. Despite the association between high lipoprotein levels and the increased risk of atherosclerosis and coronary artery disease (CAD), which, in turn, may lead to an increased risk of AF [3], several studies have suggested that high levels of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) are associated with a lower risk of AF [4]. Higher levels of TC and LDL-C were associated with lower risk of AF within the first 5 years (hazard ratios [HRs]: 0.61, 95% confidence intervals [CIs]: 0.41 to –0.99; HR: 0.64, 95% CI: 0.45 to 0.92), but the effect was attenuated after 5 years of follow-up. Since HDL-C and high TG levels are important components of metabolic syndrome, this finding may demonstrate a role of metabolic syndrome and its components in the risk of AF.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
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