Journal Article

Mindfulness- and acceptance-based interventions for patients with fibromyalgia – A systematic review and meta-analyses

Hagen, Kåre Birger, Haugmark, Trond, Zangi, Heidi A., Smedslund, Geir

2019

Overview

To analyze health effects of mindfulness- and acceptance-based interventions, including mindfulness-based stress reduction (MBSR), mindfulness-based cognitive therapy (MBCT) and acceptance and commitment therapy (ACT). Additionally, we aimed to explore content and delivery components in terms of procedure, instructors, mode, length, fidelity and adherence in the included interventions. We performed a systematic literature search in the databases MEDLINE, PsychINFO, CINAHL, EMBASE, Cochrane Central and AMED from 1990 to January 2019. We included randomized and quasi-randomized controlled trials analyzing health effects of mindfulness- and acceptance-based interventions for patients with fibromyalgia compared to no intervention, wait-list control, treatment as usual, or active interventions. MBSR combined with other treatments were included. Predefined outcomes were pain, fatigue, sleep quality, psychological distress, depression, anxiety, mindfulness, health-related quality of life and work ability. The Template for Intervention Description and Replication (TIDieR) checklist and guide was used to explore content and delivery components in the interventions. Meta-analyses were performed, and GRADE was used to assess the certainty in the evidence. The search identified 4430 records, of which nine original trials were included. The vast majority of the participants were women. The analyses showed small to moderate effects in favor of mindfulness- and acceptance-based interventions compared to controls in pain (SMD -0.46 [95% CI -0.75, -0.17]), depression (SMD -0.49 [95% CI -0.85, -0.12]), anxiety (SMD -0.37 [95% CI -0.71, -0.02]), mindfulness (SMD -0.40 [-0.69, -0.11]), sleep quality (SMD -0.33 [-0.70, 0.04]) and health-related quality of life (SMD -0.74 [95% CI -2.02, 0.54]) at end of treatment. The effects are uncertain due to individual study limitations, inconsistent results and imprecision. Health effects of mindfulness- and acceptance-based interventions for patients with fibromyalgia are promising but uncertain. Future trials should consider investigating whether strategies to improve adherence and fidelity of mindfulness- and acceptance-based interventions can improve health outcomes.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Acceptance and Commitment Therapy - methods / Accuracy / Analysis / Anxiety / Biology and Life Sciences / Care and treatment / Chronic illnesses / Clinical trials / Cognition & reasoning / Cognitive ability / Cognitive therapy / Depression (Mood disorder) / Fatigue / Female / Fibromyalgia / Fibromyalgia - psychology / Fibromyalgia - therapy / Fidelity / Health / Health psychology / Health services / Hospitals / Humans / Internal medicine / Intervention / Male / Medicine / Medicine and Health Sciences / Meditation / Mental depression / Methods / Mindfulness - methods / Outcome Assessment, Health Care / Pain / Pain management / Patient Compliance - psychology / People and Places / Physical Sciences / Public health / Quality of Life / Randomization / Rehabilitation / Research and Analysis Methods / Rheumatology / Sleep / Stress (Psychology) / Stress management / Systematic review / Teachers / Therapy